Article

A genome-wide CRISPR screen supported by human genetics identifies the <i>TNRC18</i> gene locus as a novel regulator of inflammatory signaling

2023-10-04

Abstract excerpt

<h4>ABSTRACT</h4> Interleukin-1β (IL-1β) is dysregulated in many chronic inflammatory diseases, yet the genetic factors influencing IL-1β production and signaling remain largely unknown. Myeloid-derived cells are the primary producers of IL-1β, prompting a genome-wide CRISPR knockout screen in the human myeloid-derived U937 cell model, treated with lipopolysaccharide (LPS) to mimic inflammatory conditions, and so...

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Literature Corpus work: 8dd355e0-7a0c-583e-8c32-d3a4ef4ef746
DOI: 10.1101/2023.10.04.560902

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