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Article

Signaling by IL‐12 and IL‐23 and the immunoregulatory roles of STAT4

11 Nov 2004

Abstract excerpt

Produced in response to a variety of pathogenic organisms, interleukin (IL)-12 and IL-23 are key immunoregulatory cytokines that coordinate innate and adaptive immune responses. These dimeric cytokines share a subunit, designated p40, and bind to a common receptor chain, IL-12R beta 1. The receptor for IL-12 is composed of IL-12R beta 1 and IL-12R beta 2, whereas IL-23 binds to a receptor composed of IL-12R beta...

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Identifiers

PMID: 15546391
DOI: 10.1111/j.0105-2896.2004.00211.x

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