Article

Sustained store-operated calcium entry utilizing activated chromatin state leads to instability in iTregs

2023-06-06

Abstract excerpt

Thymus-originated tTregs and in vitro induced iTregs are subsets of regulatory T cells. While they share the capacity of immune suppression, their stabilities are different, with iTregs losing their phenotype upon stimulation or under inflammatory milieu. Epigenetic differences, particularly methylation state of Foxp3 CNS2 region, provide an explanation for this shift. Whether additional regulations, including ce...

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Literature Corpus work: 6b7be595-2e8a-5291-89d0-8370b0266733
DOI: 10.1101/2023.06.04.543629

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