Article
Calcium-mediated shaping of naive CD4 T-cell phenotype and function.
eLife - 14 Dec 2017
Guichard Vincent, Bonilla Nelly, Durand Aurélie, Audemard-Verger Alexandra, Guilbert Thomas, Martin Bruno, Lucas Bruno, Auffray Cédric
Abstract excerpt
Continuous contact with self-major histocompatibility complex ligands is essential for the survival of naive CD4 T cells. We have previously shown that the resulting tonic TCR signaling also influences their fate upon activation by increasing their ability to differentiate into induced/peripheral regulatory T cells. To decipher the molecular mechanisms governing this process, we here focus on the TCR signaling...
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