Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint

1 Jan 2022

Abstract excerpt

CD21 low age-associated or atypical memory B cells are autoantibody enriched and poised for plasma cell differentiation. These cells overaccumulate in chronic infections, autoimmune disease, and immunodeficiency, posing the question of what checkpoints normally oppose their accumulation. Here, we reveal a critical role for paralogous calcium-NFAT-regulated transcription factors EGR2 and EGR3 that are induced in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35045301
DOI: 10.1016/j.celrep.2021.110259

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpointPMID 35045301Read ↗

Uncontrolled CD21 <sup>low</sup> age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpointSemantic proximity Read ↗

Uncovering Immune Surveillance Deficiency in B Cell-Driven Autoimmune DiseaseSemantic proximity Read ↗

The transcription factor Zeb2 drives formation of age-associated B cellsSemantic proximity Read ↗

Single-cell analysis reveals multi-faceted features of B cell development together with age-associated B cell subpopulationsSemantic proximity Read ↗

Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19Semantic proximity Read ↗

PRDM1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transitionSemantic proximity Read ↗

Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the PeripherySemantic proximity Read ↗

Maturation Trajectories and Transcriptional Landscape of Plasmablasts and Autoreactive B Cells in COVID-19Semantic proximity Read ↗

AP-1–independent NFAT signaling maintains follicular T cell function in infection and autoimmunitySemantic proximity Read ↗

Complex subsets but redundant clonality after B cells egress from spontaneous germinal centersSemantic proximity Read ↗

Peripheral tolerance checkpoints imposed by ubiquitous antigen expression limit antigen-specific B-cell responses under strongly immunogenic conditionsSemantic proximity Read ↗

B Cell Tolerance and BCR Signaling Dysregulation in NF155-Mediated Autoimmune NodopathiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.