Article
Ikaros sets thresholds for T cell activation and regulates chromosome propagation.
Immunity - 1 Mar 1999
Avitahl N, Winandy S, Friedrich C, Jones B, Ge Y, Georgopoulos K
Abstract excerpt
T cell activation involves the sustained accumulation of T cell receptor (TCR) and IL-2 receptor (IL-2R) mediated signaling events that promote cell cycle entry and progression. The Ikaros family of nuclear factors regulate this process by providing thresholds overcome by receptor signaling. T cells with reduced levels of Ikaros activity require fewer TCR engagement events for activation, exhibit a greater...
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