Article

Functional and Clinical Implications of Extrachromosomal Circular DNA in the Human Germline

2024-06-03

Abstract excerpt

Extrachromosomal circular DNA (eccDNA) originates from linear chromosomal DNA and can be found in various human cell types including the male germline. However, the functional effects and biogenesis mechanisms of the eccDNA in the human male germline are not well understood. Here, we developed a sequencing approach to extract eccDNA sequence information and the paired transcriptome information from the same cells....

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Literature Corpus work: 6b767cc6-03a5-5b6d-97bb-e1cd3bf453c8
DOI: 10.1101/2024.06.02.597028

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