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Identification and characterization of extrachromosomal circular DNA in maternal plasma

3 Jan 2020

Abstract excerpt

We explored the presence of extrachromosomal circular DNA (eccDNA) in the plasma of pregnant women. Through sequencing following either restriction enzyme or Tn5 transposase treatment, we identified eccDNA molecules in the plasma of pregnant women. These eccDNA molecules showed bimodal size distributions peaking at ∼202 and ∼338 bp with distinct 10-bp periodicity observed throughout the size ranges within both...

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PMID: 31900366
DOI: 10.1073/pnas.1914949117

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