Article

Single-cell sequencing unveils distinct immune microenvironment with CCR6-CCL20 crosstalk in human chronic pancreatitis

2021-04-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Chronic pancreatitis (CP) is a potentially fatal disease of the exocrine pancreas, with no specific or effective approved therapies. Due to difficulty in accessing pancreas tissues, little is known about local immune responses or pathogenesis in human CP. We sought to characterize pancreas immune responses using tissues derived from patients with different etiologies of CP an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 28a90e89-680e-5966-b26e-5acbfc60d696
DOI: 10.1101/2021.04.05.438347

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell sequencing unveils distinct immune microenvironment with CCR6-CCL20 crosstalk in human chronic pancreatitisDOI 10.1101/2021.04.05.438347Read

A multi-omics analysis of pancreatitis: bridging familial genetics and disease progression.Semantic proximity Read

Integration of scRNA-Seq and Bulk RNA-Seq Reveals Molecular Characterization of the Immune Microenvironment in Acute PancreatitisSemantic proximity Read

Single-nucleus transcriptomic analysis of pediatric pancreas reveals cellular heterogeneity and early neoplasia signatures during chronic pancreatitisSemantic proximity Read

Identification and validation of CCL28 and CCL5 as chemokine biomarkers and pro-inflammatory mediators in acute pancreatitis: an integrated bioinformatics and experimental studySemantic proximity Read

Chronic pancreatitis patient-derived organoids reveal new paths to precision therapeuticsSemantic proximity Read

Single-Cell Mapping Identifies CD14⁺ Macrophages as Central Orchestrators of CD8⁺ T Cell–Driven Immune Niches in clinical Type 1 diabetesSemantic proximity Read

PanKbase Integrated Single-Cell Map: A Comprehensive Atlas of Human Pancreatic IsletsSemantic proximity Read

Single cell RNA-seq reveals the CCL5/SDC1 receptor-ligand interaction between T cells and tumor cells in pancreatic cancerSemantic proximity Read

Analysis of Immune Cell Infiltration Characteristics in Severe Acute Pancreatitis through Integrated BioinformaticsSemantic proximity Read

Human Pancreatic Cancer Single-Cell Atlas Reveals Association of CXCL10+ Fibroblasts and Basal Subtype Tumor CellsSemantic proximity Read

Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic pancreatitis.Semantic proximity Read

CXCL12 derived from cancer-associated fibroblasts mediates dysfunctional intratumoral adaptive immunity in diabetic pancreatic adenocarcinomaSemantic proximity Read