Article

Ebolavirus Species-Specific Interferon Antagonism Mediated by VP24

2023-04-17

Abstract excerpt

Members of the Ebolavirus genus demonstrate a marked differences in pathogenicity in humans with Ebola (EBOV) being the most pathogenic, Bundibugyo (BDBV) less pathogenic and Reston (RESTV) causing no severe disease in humans. The VP24 protein encoded by members of the Ebolavirus genus blocks type I interferon (IFN-I) signaling through interaction with host karyopherin alpha nuclear transporters, potentially contr...

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Literature Corpus work: 6b3bd373-a99c-52be-a81d-ea6252dc2d0d
DOI: 10.20944/preprints202304.0389.v1

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