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Novel activities by ebolavirus and marburgvirus interferon antagonists revealed using a standardized in vitro reporter system

5 Dec 2016

Abstract excerpt

Filoviruses are highly lethal in humans and nonhuman primates, likely due to potent antagonism of host interferon (IFN) responses early in infection. Filoviral protein VP35 is implicated as the major IFN induction antagonist, while Ebola virus (EBOV) VP24 or Marburg virus (MARV) VP40 are known to block downstream IFN signaling. Despite progress elucidating EBOV and MARV antagonist function, those for most other...

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PMID: 27930961
DOI: 10.1016/j.virol.2016.11.015

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