Article

Correlating the ability of VP24 protein from Ebola and Marburg viruses to bind human karyopherin to their immune suppression mechanism and pathogenicity using computational methods

2014-12-08

Abstract excerpt

Immune response suppression is crucial for viral invasion. The protein VP24 is pivotal in achieving this in Ebola, although interestingly the mechanism of immune suppression is different in the closely related Marburg virus. Here, we illustrate that a possible molecular basis for this difference emanates from two alpha helical structures ( α 5 and α 6) in VP24 involved in binding human karyopherin (KPNA) (PDBid:...

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Literature Corpus work: fc106bae-c6d8-5c22-90ba-8fbe65974f18
DOI: 10.12688/f1000research.5666.2

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