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Article

Changes associated with Ebola virus adaptation to novel species.

Bioinformatics (Oxford, England) - 1 Jul 2017

Pappalardo Morena, Reddin Ian G, Cantoni Diego, Rossman Jeremy S, Michaelis Martin, Wass Mark N

Abstract excerpt

MOTIVATION: Ebola viruses are not pathogenic but can be adapted to replicate and cause disease in rodents. Here, we used a structural bioinformatics approach to analyze the mutations associated with Ebola virus adaptation to rodents to elucidate the determinants of host-specific Ebola virus pathogenicity. RESULTS: We identified 33 different mutations associated with Ebola virus adaptation to rodents in the...

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PMID: 28200119
DOI: 10.1093/bioinformatics/btx065

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