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Assessing the contribution of interferon antagonism to the virulence of West African Ebola viruses

5 Aug 2015

Abstract excerpt

The current Ebola virus (EBOV) outbreak in West Africa is unprecedented in terms of both its size and duration, and there has been speculation and concern regarding the potential for EBOV to increase in virulence as a result of its prolonged circulation in humans. Here we investigate the relative potency of the interferon (IFN) inhibitors encoded by EBOVs from West Africa, since an important EBOV virulence factor...

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PMID: 26242723
DOI: 10.1038/ncomms9000

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