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Article

Conserved differences in protein sequence determine the human pathogenicity of Ebolaviruses.

Scientific reports - 24 Mar 2016

Pappalardo Morena, Juliá Miguel, Howard Mark J, Rossman Jeremy S, Michaelis Martin, Wass Mark N

Abstract excerpt

Reston viruses are the only Ebolaviruses that are not pathogenic in humans. We analyzed 196 Ebolavirus genomes and identified specificity determining positions (SDPs) in all nine Ebolavirus proteins that distinguish Reston viruses from the four human pathogenic Ebolaviruses. A subset of these SDPs will explain the differences in human pathogenicity between Reston and the other four ebolavirus species. Structural...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27009368
DOI: 10.1038/srep23743
PMCID: PMC4806318

Genes

KPNA5

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