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Article

Evasion of Interferon Responses by Ebola and Marburg Viruses

20 Aug 2009

Abstract excerpt

The filoviruses, Ebola virus (EBOV) and Marburg virus (MARV), cause frequently lethal viral hemorrhagic fever. These infections induce potent cytokine production, yet these host responses fail to prevent systemic virus replication. Consistent with this, filoviruses have been found to encode proteins VP35 and VP24 that block host interferon (IFN)-alpha/beta production and inhibit signaling downstream of the...

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PMID: 19694547
DOI: 10.1089/jir.2009.0076

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