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Article

Ebolavirus VP24 binding to karyopherins is required for inhibition of interferon signaling.

Journal of virology - 1 Jan 2010

Mateo Mathieu, Reid St Patrick, Leung Lawrence W, Basler Christopher F, Volchkov Viktor E

Abstract excerpt

The Ebolavirus VP24 protein counteracts alpha/beta interferon (IFN-alpha/beta) and IFN-gamma signaling by blocking the nuclear accumulation of tyrosine-phosphorylated STAT1 (PY-STAT1). According to the proposed model, VP24 binding to members of the NPI-1 subfamily of karyopherin alpha (KPNalpha) nuclear localization signal receptors prevents their binding to PY-STAT1, thereby preventing PY-STAT1 nuclear...

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Share to alpha Karyopherins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19889762
DOI: 10.1128/JVI.01372-09
PMCID: PMC2798383

Genes

STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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