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Article

Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins

1 Feb 2016

Abstract excerpt

Suppression of innate immune responses during filoviral infection contributes to disease severity. Ebola (EBOV) and Marburg (MARV) viruses each encode a VP35 protein that suppresses RIG-I-like receptor signaling and interferon-α/β (IFN-α/β) production by several mechanisms, including direct binding to double stranded RNA (dsRNA). Here, we demonstrate that in cell culture, MARV infection results in a greater...

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Identifiers

PMID: 26876165
DOI: 10.1016/j.celrep.2016.01.049

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