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Article

Expression of the Ebola Virus VP24 Protein Compromises the Integrity of the Nuclear Envelope and Induces a Laminopathy-Like Cellular Phenotype.

mBio - 31 Aug 2021

Vidal Santiago, Sánchez-Aparicio Maite, Seoane Rocío, El Motiam Ahmed, Nelson Emily V, Bouzaher Yanis H, Baz-Martínez Maite, García-Dorival Isabel, Gonzalo Susana, Vázquez Enrique, Vidal Anxo, Muñoz-Fontela César, García-Sastre Adolfo, Rivas Carmen

Abstract excerpt

Ebola virus (EBOV) VP24 protein is a nucleocapsid-associated protein that inhibits interferon (IFN) gene expression and counteracts the IFN-mediated antiviral response, preventing nuclear import of signal transducer and activator of transcription 1 (STAT1). Proteomic studies to identify additional EBOV VP24 partners have pointed to the nuclear membrane component emerin as a potential element of the VP24 cellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34225493
DOI: 10.1128/mBio.00972-21
PMCID: PMC8406168

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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