Article

Massively parallel reporter assay reveals promoter-, position-, and strand-specific effects in transcription start sites

2025-10-14

Abstract excerpt

<h4>ABSTRACT</h4> Massively parallel reporter assays (MPRA) are a high-throughput method of assessing the activity of candidate cis-regulatory sequences, and can be used to detect allelic differences at disease-associated variants. Previous MPRA studies have screened thousands of functional SNPs associated with various complex traits and conditions. Most MPRA libraries utilize a single plasmid configuration, a si...

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Literature Corpus work: 0c5a1b99-f3df-562b-a975-19bc4daf906e
DOI: 10.1101/2025.10.13.659964

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