Article

Systematic comparison of estimates of transcription factor activity by ATAC-seq and multiplexed reporter assays

2026-01-05

Abstract excerpt

<h4>ABSTRACT</h4> Transcription factors (TFs) are central to gene regulation and play critical roles in development, cellular homeostasis and disease. The ability to accurately measure TF activity is essential to understanding how TFs respond to signals and regulate target genes. In one commonly used approach, activities of TFs are computationally inferred from genome-wide chromatin accessibility data (ATAC-seq)....

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Literature Corpus work: 10c5db16-31fa-5fe0-b965-30dfced24bc3
DOI: 10.64898/2026.01.05.697632

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