Article

Structured and disordered regions of Ataxin-2 contribute differently to the specificity and efficiency of mRNP granule formation

2022-02-17

Abstract excerpt

<h4>ABSTRACT</h4> Ataxin-2 ( ATXN2 ) is a gene implicated in spinocerebellar ataxia type II (SCA2), amyotrophic lateral sclerosis (ALS) and Parkinsonism. The encoded protein is a therapeutic target for ALS and related conditions. ATXN2 (or Atx2 in insects) can function in translational activation, translational repression, mRNA stability and in the assembly of mRNP-granules, a process mediated by intrinsically d...

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Literature Corpus work: 6aef1a9d-b78a-5182-bed9-ce4e00209e43
DOI: 10.1101/2022.02.15.480566

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