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Structured and disordered regions of Ataxin-2 contribute differently to the specificity and efficiency of mRNP granule formation

20 May 2024

Abstract excerpt

Ataxin-2 (ATXN2) is a gene implicated in spinocerebellar ataxia type II (SCA2), amyotrophic lateral sclerosis (ALS) and Parkinsonism. The encoded protein is a therapeutic target for ALS and related conditions. ATXN2 (or Atx2 in insects) can function in translational activation, translational repression, mRNA stability and in the assembly of mRNP-granules, a process mediated by intrinsically disordered regions...

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PMID: 38768217
DOI: 10.1371/journal.pgen.1011251

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