Article

Bioinformatic Analyses of the Ataxin-2 Family Since Algae Emphasize Its Small Isoforms, Large Chimerisms, and the Importance of Human Exon 1B as Target of Therapies to Prevent Neurodegeneration

2026-01-12

Abstract excerpt

Polyglutamine expansion in Ataxin-2 (ATXN2) is responsible for rare, dominantly in-herited Spinocerebellar Ataxia type 2 (SCA2). Together with its paralog Ataxin-2-like (ATXN2L), both proteins received much interest since deletion of their yeast and fly orthologs alleviates TDP-43-triggered neurotoxicity in Amyotrophic Lateral Sclerosis models. Their typical structure across evolution combines LSm with LSm-Associa...

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Literature Corpus work: da5aaa1a-2f89-5b34-a6d9-913ec3878279
DOI: 10.20944/preprints202601.0750.v1

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Bioinformatic Analyses of the Ataxin-2 Family Since Algae Emphasize Its Small Isoforms, Large Chimerisms, and the Importance of Human Exon 1B as Target of Therapies to Prevent NeurodegenerationDOI 10.20944/preprints202601.0750.v1Read

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