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Article

An integrative approach to gain insights into the cellular function of human ataxin-2.

Journal of molecular biology - 11 Feb 2005

Ralser Markus, Albrecht Mario, Nonhoff Ute, Lengauer Thomas, Lehrach Hans, Krobitsch Sylvia

Abstract excerpt

Spinocerebellar ataxia type 2 (SCA2) is a hereditary neurodegenerative disorder caused by a trinucleotide expansion in the SCA2 gene, encoding a polyglutamine stretch in the gene product ataxin-2 (ATX2), whose cellular function is unknown. However, ATX2 interacts with A2BP1, a protein containing an RNA-recognition motif, and the existence of an interaction motif for the C-terminal domain of the poly(A)-binding...

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Identifiers

PMID: 15663938
DOI: 10.1016/j.jmb.2004.11.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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