Article

Distinct Cellular Effects of Myotonic Dystrophy type 2 RAN Tetrapeptides in <i>Drosophila melanogaster</i>

2025-10-28

Abstract excerpt

<h4>ABSTRACT</h4> Myotonic dystrophy type 2 (DM2) is an autosomal dominant, multisystemic disorder caused by the expansion of CCTG repeats in the first intron of the CNBP gene. Repeat-associated non-AUG (RAN) translation of the expanded CCTG RNA may produce two tetrapeptide repeat proteins (TPRs), poly-QAGR and poly-PACL, whose roles in DM2 pathogenesis remain poorly understood. To investigate their individual co...

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Literature Corpus work: 702264c9-bc31-52d1-aa54-8dab64e85ab9
DOI: 10.1101/2025.10.28.685039

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