Article

<i>RNA toxicity and perturbation of</i> rRNA processing in spinocerebellar ataxia type 2

2021-05-09

Abstract excerpt

<h4>BACKGROUND</h4> Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disease caused by expansion of a CAG repeat in Ataxin-2 ( ATXN2 ) gene. The mutant ATXN2 protein with a polyglutamine tract is known to be toxic and contributes to the SCA2 pathogenesis. <h4>OBJECTIVE</h4> Here we tested the hypothesis that the mutant ATXN2 transcript with an expanded CAG repeat ( expATXN2 ) is also toxic and co...

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Literature Corpus work: 1e5e4cf4-d1a3-531e-92f6-c6c4faddc176
DOI: 10.1101/2021.05.07.443200

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