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Article

Direct binding of Ataxin-2 to distinct elements in 3' UTRs promotes mRNA stability and protein expression.

Molecular cell - 17 Jul 2014

Yokoshi Moe, Li Quan, Yamamoto Munetaka, Okada Hitomi, Suzuki Yutaka, Kawahara Yukio

Abstract excerpt

It has been proposed that Ataxin-2, a member of the like-Sm (LSm) protein family, participates in the regulation of RNA metabolism through interaction with PABPC1. However, the exact biological mechanism and in vivo targets remain unknown. Here, we report that Ataxin-2 binds directly to RNAs in a PABPC1-independent manner. High-throughput sequencing of Ataxin-2-bound RNAs prepared by PAR-CLIP revealed that...

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Share to 3' Untranslated Regions
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24954906
DOI: 10.1016/j.molcel.2014.05.022

Genes

PABPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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