Article

Life without mismatch repair

2021-04-15

Abstract excerpt

Mismatch repair (MMR) is a critical defence against mutation, but we lack quantification of its activity on different DNA lesions during human life. We performed whole-genome sequencing of normal and neoplastic tissues from individuals with constitutional MMR deficiency to establish the roles of MMR components, tissue type and disease state in somatic mutation rates. Mutational signatures varied extensively across...

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Literature Corpus work: 6ae635ea-f1b8-5720-b4ce-107ff86b3281
DOI: 10.1101/2021.04.14.437578

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