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Mismatch Repair Pathway, Genome Stability and Cancer

26 Jun 2020

Abstract excerpt

The acquisition of genomic instability is one of the key characteristics of the cancer cell, and microsatellite instability (MSI) is an important segment of this phenomenon. This review aims to describe the mismatch DNA repair (MMR) system whose deficiency is responsible for MSI and discuss the cellular roles of MMR genes. Malfunctioning of the MMR repair pathway increases the mutational burden of specific...

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PMID: 32671096
DOI: 10.3389/fmolb.2020.00122

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