Article
DNA mismatch repair: molecular mechanism, cancer, and ageing.
Mechanisms of ageing and development - 1 Jan 2000
Hsieh Peggy, Yamane Kazuhiko
Abstract excerpt
DNA mismatch repair (MMR) proteins are ubiquitous players in a diverse array of important cellular functions. In its role in post-replication repair, MMR safeguards the genome correcting base mispairs arising as a result of replication errors. Loss of MMR results in greatly increased rates of spontaneous mutation in organisms ranging from bacteria to humans. Mutations in MMR genes cause hereditary nonpolyposis...
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