Article

Deficiency in DNA mismatch repair of methylation damage is a major mutational process in cancer

2020-11-18

Abstract excerpt

DNA mismatch repair (MMR) is essential for maintaining genome integrity with its deficiency predisposing to cancer 1 . MMR is well known for its role in the post-replicative repair of mismatched base pairs that escape proofreading by DNA polymerases following cell division 2 . Yet, cancer genome sequencing has revealed that MMR deficient cancers not only have high mutation burden but also harbour multiple mutati...

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Literature Corpus work: 930de462-fb69-594d-997b-5d099a282c2b
DOI: 10.1101/2020.11.18.388108

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