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Mismatch repair deficiency: The what, how and why it is important

27 Nov 2021

Abstract excerpt

The mismatch repair system is a major pathway that functions in the maintenance of genomic integrity. It is involved in mitotic and meiotic recombination, apoptosis, immunoglobulin gene rearrangement, somatic hypermutation, and other processes. Deficiencies in mismatch repair give rise to hypermutability and the phenomenon called microsatellite instability. Detection of deficient mismatch repair function or...

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PMID: 34837268
DOI: 10.1002/gcc.23015

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