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DNA mismatch repair and cancer

1 Jan 2003

Abstract excerpt

DNA mismatch repair (MMR) is an important genome caretaker system. It ensures genomic stability by correcting mismatches generated during DNA replication and recombination and by triggering apoptosis of cells with large amounts of DNA damage. Protein components responsible for these reactions are highly conserved through evolution, and homologs of bacterial MutS and MutL, which are key players in the initiation...

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PMID: 12700127
DOI: 10.2741/1121

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