Article

Bulk Tissue Cell Type Deconvolution with Multi-Subject Single-Cell Expression Reference

2018-06-26

Abstract excerpt

We present MuSiC, a method that utilizes cell-type specific gene expression from single-cell RNA sequencing (RNA-seq) data to characterize cell type compositions from bulk RNA-seq data in complex tissues. When applied to pancreatic islet and whole kidney expression data in human, mouse, and rats, MuSiC outperformed existing methods, especially for tissues with closely related cell types. MuSiC enables characteriza...

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Literature Corpus work: 6ad396c1-c9f8-59f5-943e-7d54c80a6e18
DOI: 10.1101/354944

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