Article

<i>imply</i> : improving cell-type deconvolution accuracy using personalized reference profiles

2023-09-29

Abstract excerpt

Real-world clinical samples are often admixtures of signal mosaics from multiple pure cell types. Using computational tools, bulk transcriptomics can be deconvoluted to solve for the abundance of constituent cell types. However, existing deconvolution methods are conditioned on the assumption that the whole study population is served by a single reference panel, which ignores person-to-person heterogeneity. Here w...

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Literature Corpus work: 8a9c59e5-5dc7-563c-a855-d6a6c1a65801
DOI: 10.1101/2023.09.27.559579

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