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Accurate estimation of cell composition in bulk expression through robust integration of single-cell information

24 Apr 2020

Abstract excerpt

We present Bisque, a tool for estimating cell type proportions in bulk expression. Bisque implements a regression-based approach that utilizes single-cell RNA-seq (scRNA-seq) or single-nucleus RNA-seq (snRNA-seq) data to generate a reference expression profile and learn gene-specific bulk expression transformations to robustly decompose RNA-seq data. These transformations significantly improve decomposition...

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PMID: 32332754
DOI: 10.1038/s41467-020-15816-6

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