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Bulk tissue cell type deconvolution with multi-subject single-cell expression reference

22 Jan 2019

Abstract excerpt

Knowledge of cell type composition in disease relevant tissues is an important step towards the identification of cellular targets of disease. We present MuSiC, a method that utilizes cell-type specific gene expression from single-cell RNA sequencing (RNA-seq) data to characterize cell type compositions from bulk RNA-seq data in complex tissues. By appropriate weighting of genes showing cross-subject and...

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PMID: 30670690
DOI: 10.1038/s41467-018-08023-x

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