Article

Highly accurate estimation of cell type abundance in bulk tissues based on single-cell reference and domain adaptive matching

2023-07-25

Abstract excerpt

Accurately identifying the cellular composition of complex tissues is critical for understanding disease pathogenesis, early diagnosis, and prevention. However, current methods for deconvoluting bulk RNA sequencing (RNA-seq) typically rely on matched single-cell RNA sequencing (scRNA-seq) as a reference, which can be limiting due to differences in sequencing distribution and the potential for invalid information f...

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Literature Corpus work: 829bc7a1-7478-5477-8d17-9d9da9a49851
DOI: 10.1101/2023.07.22.550132

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