Article

Accurate estimation of cell-type resolution transcriptome in bulk tissue through matrix completion

2021-07-01

Abstract excerpt

Single cell RNA-seq (scRNA-seq) has been widely used to uncover cellular heterogeneity, however, the constraints of cost make it impractical as a routine on large patient cohorts. Here we present ENIGMA, a method that accurately deconvolute bulk tissue RNA-seq into single cell-type resolution given the knowledge gained from scRNA-seq. ENIGMA applies a matrix completion strategy to minimize the distance between mix...

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Literature Corpus work: c5c532cd-e24a-5893-be4c-9697841ead59
DOI: 10.1101/2021.06.30.450493

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