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Article

Microglial Homeostasis Requires Balanced CSF-1/CSF-2 Receptor Signaling.

Cell reports - 3 Mar 2020

Chitu Violeta, Biundo Fabrizio, Shlager Gabriel G L, Park Eun S, Wang Ping, Gulinello Maria E, Gokhan Şölen, Ketchum Harmony C, Saha Kusumika, DeTure Michael A, Dickson Dennis W, Wszolek Zbignew K, Zheng Deyou, Croxford Andrew L, Becher Burkhard, Sun Daqian, Mehler Mark F, Stanley E Richard

Abstract excerpt

CSF-1R haploinsufficiency causes adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). Previous studies in the Csf1r+/- mouse model of ALSP hypothesized a central role of elevated cerebral Csf2 expression. Here, we show that monoallelic deletion of Csf2 rescues most behavioral deficits and histopathological changes in Csf1r+/- mice by preventing microgliosis and eliminating most...

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Identifiers

PMID: 32130903
DOI: 10.1016/j.celrep.2020.02.028
PMCID: PMC7370656

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