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Article

Insulin and hypoxia share common target genes but not the hypoxia-inducible factor-1alpha.

The Journal of biological chemistry - 3 Oct 2003

Yim Sujin, Choi Su Mi, Choi Youngyeon, Lee Naery, Chung Jieun, Park Hyunsung

Abstract excerpt

Both hypoxia and insulin induce common target genes, including vascular endothelial growth factors and several glycolytic enzymes. However, these two signals eventually trigger quite different metabolic pathways. Hypoxia induces glycolysis, resulting in anaerobic ATP production, while insulin inc...

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PMID: 12876287
DOI: 10.1074/jbc.M306016200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12876287-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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