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β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes

1 May 2019

Abstract excerpt

The development of autoimmune disease type 1 diabetes (T1D) is determined by both genetic background and environmental factors. Environmental triggers include RNA viruses, particularly coxsackievirus (CV), but how they induce T1D is not understood. Here, we demonstrate that deletion of the transcription factor hypoxia-inducible factor-1α (HIF-1α) from β cells increases the susceptibility of non-obese diabetic...

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PMID: 31116982
DOI: 10.1016/j.celrep.2019.04.086

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