Article

SCOUT: Ornstein–Uhlenbeck modelling of gene expression evolution on single-cell lineage trees

2025-11-13

Abstract excerpt

Understanding the evolutionary dynamics of clonal populations is essential for uncovering the principles of development, disease progression, and therapeutic resistance. Recent advances in single-cell lineage tracing and transcriptomics enable such analyses by combining heritable barcodes with cell-state information. Here, we present SCOUT ( s ingle- c ell O rnstein– U hlenbeck t rees), a framework that model...

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Literature Corpus work: 188b0021-da0e-5f7e-b321-40930f7064c7
DOI: 10.1101/2025.11.12.688020

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