Article

ATF7IP2/MCAF2 directs H3K9 methylation and meiotic gene regulation in the male germline

2023-10-02

Abstract excerpt

H3K9 tri-methylation (H3K9me3) plays emerging roles in gene regulation, beyond its accumulation on pericentric constitutive heterochromatin. It remains a mystery why and how H3K9me3 undergoes dynamic regulation in male meiosis. Here, we identify a novel, critical regulator of H3K9 methylation and spermatogenic heterochromatin organization: the germline-specific protein ATF7IP2 (MCAF2). We show that, in male meiosi...

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Literature Corpus work: 6a9c4f39-98c4-5914-8c5a-a16de4610f9e
DOI: 10.1101/2023.09.30.560314

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