Article

Mutational bias in spermatogonia impacts the anatomy of regulatory sites in the human genome

2021-06-10

Abstract excerpt

Mutation in the germline is the ultimate source of genetic variation, but little is known about the influence of germline chromatin structure on mutational processes. Using ATAC-seq, we profile the open chromatin landscape of human spermatogonia, the most proliferative cell-type of the germline, identifying transcription factor binding sites (TFBSs) and PRDM9-binding sites, a subset of which will initiate meiotic...

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Literature Corpus work: e658da28-e322-5748-9fb7-08ffe0bb452c
DOI: 10.1101/2021.06.10.447556

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