Article
FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis.
Human molecular genetics - 15 Sept 2015
Kato Yasuko, Alavattam Kris G, Sin Ho-Su, Meetei Amom Ruhikanta, Pang Qishen, Andreassen Paul R, Namekawa Satoshi H
Abstract excerpt
Fanconi anemia (FA) is a recessive X-linked and autosomal genetic disease associated with bone marrow failure and increased cancer, as well as severe germline defects such as hypogonadism and germ cell depletion. Although deficiencies in FA factors are commonly associated with germ cell defects, it remains unknown whether the FA pathway is involved in unique epigenetic events in germ cells. In this study, we...
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