Article

Transcription factor NFYA directs male meiotic entry by facilitating accessible chromatin at meiotic promoters in mice

2025-05-14

Abstract excerpt

<h4>SUMMARY</h4> Meiotic prophase I characterized by homologous recombination and synapsis is an intricate step for spermatogenesis. This process entails extensive changes to chromatin and transcription. Prior to prophase I, accessible chromatin bound by paused Pol II at meiotic gene promoters is essential for their timely activation later during meiosis. However, the factor responsible for promoting accessible c...

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Literature Corpus work: 35a1210f-af05-588c-bb7c-91d4e60cef81
DOI: 10.1101/2025.05.09.653044

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