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Article

Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes

16 Aug 2022

Abstract excerpt

Sensing of cytosolic DNA of microbial or cellular/mitochondrial origin by cGAS initiates innate immune responses via the adaptor protein STING. It remains unresolved how the activity of STING is balanced between a productive innate immune response and induction of autoimmunity. Here we show that interferon regulatory factor 8 (IRF8) is essential for efficient activation of STING-mediated innate immune responses...

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PMID: 35973990
DOI: 10.1038/s41467-022-32401-1

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