Article

Differential vulnerability of CA1 pyramidal neuron cell types in the 5xFAD Alzheimer’s disease mouse model

2026-06-02

Abstract excerpt

Selective neuronal vulnerability is a defining feature of Alzheimer’s disease, yet how neurodegeneration unfolds across defined hippocampal CA1 pyramidal neuron populations remains unresolved. Previously, we showed that CA1 pyramidal neurons are organized into molecularly defined laminar cell types that form stable spatial signatures along the longitudinal axis (Pachicano et al., 2025). Here, we investigated how v...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6a7ab03b-a62e-553e-b89b-ef1a51b56883
DOI: 10.64898/2026.05.29.728864

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Differential vulnerability of CA1 pyramidal neuron cell types in the 5xFAD Alzheimer’s disease mouse modelDOI 10.64898/2026.05.29.728864Read

Cellular underpinnings of the selective vulnerability to tauopathic insults in Alzheimer’s diseaseSemantic proximity Read

Single-nucleus transcriptomics identifies a shared vulnerable excitatory neuronal population across typical and atypical Alzheimer’s diseaseSemantic proximity Read

Conserved cell-type specific signature of resilience to Alzheimer’s disease nominates role for excitatory intratelencephalic cortical neuronsSemantic proximity Read

Selective neuronal vulnerability in Alzheimer’s disease: a network-based analysisSemantic proximity Read

Early Alzheimer’s disease pathology in human cortex is associated with a transient phase of distinct cell statesSemantic proximity Read

Multiregional single-cell profiling reveals shared and specialized cellular vulnerability in Alzheimer’s diseaseSemantic proximity Read

Single-cell anatomical analysis of human hippocampus and entorhinal cortex uncovers early-stage molecular pathology in Alzheimer’s diseaseSemantic proximity Read

Whole-Brain Single-Neuron Atlas Reveals Microglial Security Hole Accelerating Neuronal VulnerabilitySemantic proximity Read

Mapping Alzheimer′s neuropathology signatures to the whole brain transcriptome using machine learning data fusionSemantic proximity Read

Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditionsSemantic proximity Read

Distinctive Whole-brain Cell Types Predict Tissue Damage Patterns in Thirteen Neurodegenerative ConditionsSemantic proximity Read

Integrated multimodal cell atlas of Alzheimer’s diseaseSemantic proximity Read